Episode 7

How Cryocompression is Fast Becoming The Future of CIPN Treatment

Chemotherapy-induced peripheral neuropathy is an unseen, but lifelong and potentially debilitating  chemotherapy side effect. With very few treatment interventions, prevention and reversal of CIPN has been largely unsuccessful to this point. Clinicians have witnessed patients using off the shelf cryotherapy options, but they are unmeasured, untested, and often ineffective.

Dr Charles Loprizini sits down with oncologists and researchers to discuss what we already know about CIPN’ its impact on physical and psychological quality of life, and why the development of a new cryocompression device is showing real promise in preventing the condition as the  next stage of trials begins.

Key topics discussed:

05:57 - What is chemotherapy-induced alopecia?

09:06 - Patient-reported outcomes are needed to assess CIPN

11:39 - Dr Aishwarya Bandla discusses clinical trials looking at cryotherapy for managing CIPN

12:36 - Dr Melissa Accordino explains the pilot study looking at cryocompression at Columbia

13:33 - Dr Raghav Sundar brings us up to speed of the history of using cryotherapy to mitigate CIPN, and the development of the new Paxman Limb Cryocompression System (PLCS)

19:39 - Dr Aishwarya Bandla explains the development of the PLCS in Singapore

21:51 - Patient advocate, Anne Marie Mercurio, discusses the importance of addressing all chemotherapy-induced side effects - as these are cumulative

 

Guests

Dr Charles Loprinzi with Dr Melissa Accordino, Dr Aishwarya Bandla, Dr Stephanie Graff, Anne Marie Mercurio and Dr Raghav Sundar.

Clinical Studies Discussed

  • Loprinzi C, et al. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. Journal of Clinical Oncology 2020 38:28, 3325-3348
  • Jordan B, et al. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO-EONS-EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up. Ann Oncol. 2020 Oct;31(10):1306-1319.
  • Kanbayashi Y, et al. Comparison of the efficacy of cryotherapy and compression therapy for preventing nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A prospective self-controlled trial. Breast. 2020 Feb;49:219-224.
  • Shigematsu H, et al. Cryotherapy for the prevention of weekly paclitaxel-induced peripheral adverse events in breast cancer patients. Support Care Cancer. 2020 Oct;28(10):5005-5011.
  • Schmid P et al. Pembrolizumab for Early Triple-Negative Breast Cancer. N Engl J Med 2020; 382:810-821.
  • Filter by ‘Chemotherapy Side Effect’ on the Scalp Cooling Studies Website for more clinical studies on the use of cryotherapy for CIPN: scalpcoolingstudies.com
Download full transcript
Episode 7
How Cryocompression is Fast Becoming The Future of CIPN Treatment

Chemotherapy-induced peripheral neuropathy is an unseen, but lifelong and potentially debilitating  chemotherapy side effect. With very few treatment interventions, prevention and reversal of CIPN has been largely unsuccessful to this point. Clinicians have witnessed patients using off the shelf cryotherapy options, but they are unmeasured, untested, and often ineffective.

Dr Charles Loprizini sits down with oncologists and researchers to discuss what we already know about CIPN’ its impact on physical and psychological quality of life, and why the development of a new cryocompression device is showing real promise in preventing the condition as the  next stage of trials begins.

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About this Episode

Chemotherapy-induced peripheral neuropathy is an unseen, but lifelong and potentially debilitating  chemotherapy side effect. With very few treatment interventions, prevention and reversal of CIPN has been largely unsuccessful to this point. Clinicians have witnessed patients using off the shelf cryotherapy options, but they are unmeasured, untested, and often ineffective.

Dr Charles Loprizini sits down with oncologists and researchers to discuss what we already know about CIPN’ its impact on physical and psychological quality of life, and why the development of a new cryocompression device is showing real promise in preventing the condition as the  next stage of trials begins.

Key Topics Discussed

05:57 - What is chemotherapy-induced alopecia?

09:06 - Patient-reported outcomes are needed to assess CIPN

11:39 - Dr Aishwarya Bandla discusses clinical trials looking at cryotherapy for managing CIPN

12:36 - Dr Melissa Accordino explains the pilot study looking at cryocompression at Columbia

13:33 - Dr Raghav Sundar brings us up to speed of the history of using cryotherapy to mitigate CIPN, and the development of the new Paxman Limb Cryocompression System (PLCS)

19:39 - Dr Aishwarya Bandla explains the development of the PLCS in Singapore

21:51 - Patient advocate, Anne Marie Mercurio, discusses the importance of addressing all chemotherapy-induced side effects - as these are cumulative

 

Guests

Dr Charles Loprinzi with Dr Melissa Accordino, Dr Aishwarya Bandla, Dr Stephanie Graff, Anne Marie Mercurio and Dr Raghav Sundar.

Shownotes

  • Loprinzi C, et al. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. Journal of Clinical Oncology 2020 38:28, 3325-3348
  • Jordan B, et al. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO-EONS-EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up. Ann Oncol. 2020 Oct;31(10):1306-1319.
  • Kanbayashi Y, et al. Comparison of the efficacy of cryotherapy and compression therapy for preventing nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A prospective self-controlled trial. Breast. 2020 Feb;49:219-224.
  • Shigematsu H, et al. Cryotherapy for the prevention of weekly paclitaxel-induced peripheral adverse events in breast cancer patients. Support Care Cancer. 2020 Oct;28(10):5005-5011.
  • Schmid P et al. Pembrolizumab for Early Triple-Negative Breast Cancer. N Engl J Med 2020; 382:810-821.
  • Filter by ‘Chemotherapy Side Effect’ on the Scalp Cooling Studies Website for more clinical studies on the use of cryotherapy for CIPN: scalpcoolingstudies.com

Transcript

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