PAXMAN RESEARCH AND
 DEVELOPMENT

Together, the University of Huddersfield and Paxman are leading exciting and important multi-disciplinary scalp cooling and hair follicle research

About

The aim of the Research and Innovation Centre is to be a global leader in its field, pushing the boundaries of human knowledge while also developing cutting-edge products. Creating the best possible outcome for the patient will always be our first priority.

At the beginning of 2019, Paxman and the University of Huddersfield initiated a multi-disciplinary research group, collaborating across the School of Applied Sciences and the School of Art, Design and Architecture.

The Centre focuses on biological hair follicle research as well as developing innovative scalp cooling-related treatments and individual 3D-printed cooling caps.

Our three main areas of focus are:

1.
Development of an individual 3D-printed eco cooling cap, ready for mass production.
2.
Biological research using the most clinically relevant in vitro models, specifically cultivated human hair follicles. Learn more about the mechanisms of scalp cooling.
3.
Development of a topical product with the potential to substantially enhance the effect of scalp cooling.

Product Development

Development of an ecosystem for 3D-printed individual cooling caps.
Individually designed cooling caps tailored to each patient’s scalp could provide increased efficacy with the use of the current Paxman Scalp Cooling System. The individually cooling caps are planned to be manufactured in recyclable and environmentally friendly materials.
Want to know more?
Get in touch >

Biological Research at the Centre

For the team at the centre, it has been imperative to have a better understanding of the cellular mechanisms by which cooling reduces the chemotoxic effect on rapidly dividing hair follicle cells.

This understanding has allowed them to both predict which chemotherapy regimens will prove to be most challenging when used in conjunction with scalp cooling, and find solutions to increase efficacy and hair retention.

Previously, it was thought that vasoconstriction was the only mechanism in which scalp cooling reduced the cytotoxicity of chemotherapy drugs, however further in vitro experiments have revealed other protective effects – such as reduced drug uptake, reduced metabolic activity, and reduced rate of hair follicle cell division.

The primary focus of the biological team at the research centre will be to apply their discoveries around the mechanisms of scalp cooling within the lab, to further increase hair retention for any patient undergoing chemotherapy worldwide once applied in the clinic.

The Science

Development of the Topical Agent

Understanding the biological mechanisms of scalp cooling has led to the development of a topically applied product that enhances the effect of the treatment.

The topical agent aims to deliver to the hair follicles a molecule with strong antioxidant properties, in order to suppress the generation and/or the action of the highly damaging reactive oxygen species (radicals), generated inside cells, after chemotherapy treatment.

Biological work at the centre has provided evidence that a panel of antioxidants with different potencies, can be combined with cooling to suppress or completely inhibit chemotherapy drug-mediated cytotoxicity.

Research so far has provided strong evidence on the efficacy of the combination of cooling and treatment with antioxidants. This is an exciting development that could revolutionise the efficacy of scalp cooling in the near future, rendering scalp cooling almost 100% effective clinically.

The aim is to be able to formulate an agent in such a way that it can be applied topically to the scalp just before drug infusion. The formulation will promote the efficient delivery of the antioxidant to the follicle’s rapidly dividing cells to protect from chemotherapy-mediated toxicity.

Or view the Cooling-mediated protection from chemotherapy drug-induced cytotoxicity on scalpcoolingstudies.com >

Research & Development Team

Meet Paxman’s Research & Development team, dedicated to improving and innovating our products to ensure the best possible outcomes for patients. Paxman works alongside The University of Huddersfield in our research to better understand the cellular mechanisms by which cooling reduces the cytotoxic effects of chemotherapy on rapidly dividing hair follicle cells.

The Paxman Research & Development team work in conjunction with a plethora of international universities including Huddersfield, Leeds, Sheffield, Kings College London and has fuelled some of our most far reaching and exciting research to date. We are also proud to work alongside various other academic institutions and with some of the best minds within the fields of biological research, product development and clinical research to ensure we are pushing boundaries to develop the highest quality work and most innovative solutions.

Meet the team behind our innovation

Patrick Burke (BSc Hons)

Head of Research & Development

Patrick, currently Head of R&D at Paxman, has previously held roles in Quality, Production, and Operations within the company. His journey began in 2007 as a Technical Manager, leveraging over 30 years of engineering experience and hons degree in Maths.

Patrick initially worked on the Orbis systems which included development and regulatory pathway approvals. Patrick was responsible for securing funding through Kirklees innovation vouchers and winning a 400K Smart award in 2012, leading to a long and successful collaboration with the University of Huddersfield.

His achievements include securing Outstanding-rated Knowledge Transfer Partnerships (KTP) for biological research in 2012 and design in 2015. Patrick's contributions extend to obtaining US and Japanese approvals in 2017 and 2018, respectively, solidifying Paxman's global presence.

Jonathan Binder (MA, BA Hons)

Lead Product Designer

Jonathan serves as the Lead Product Designer at Paxman and is a Medical Researcher/Medical Product Designer at the Paxman Research & Innovation Centre, the world's first Scalp cooling and research innovation centre. With over 8+ years of industrial experience and 6+ years in academia, Jonathan is currently pursuing a part-time PhD on 'Mass Customization in Cranial Anthropology for Medical Product Development.'

His master's thesis, co-funded by Paxman and Innovate UK, explored 'Additive Manufacturing in New Medical Product Development for Chemotherapy-Induced Alopecia,' earned Jonathan a Distinction and an 'outstanding' rating for the Knowledge Transfer Partnership (KTP) from the governing body.

Jonathan has contributed to 15+ academic outputs and holds patents, highlighting his expertise in New Medical Product Development, Design for Manufacture, Design for Additive Manufacturing, and more, with a focus on CAD using Solidworks complex surfacing.

Dr Ertu Unver (PhD, MSc, BSc, PgCert, Asscociate Prof.)

Principal Enterprise Fellow

Dr. Ertu Unver, a Principal Enterprise Fellow at the University of Huddersfield since 2014., serves as the principal investigator for the Paxman Research & Innovation Centre. With extensive commercial industry experience both in the UK and abroad, he previously worked as an Industrial Designer & CAD/CAM manager, contributing significantly to the design of various consumer products. Dr. Unver holds a BSc in Mechanical Engineering (1986) and completed his MSc in Industrial Design & Computer Programming in 1989. Following the completion of his PhD, he became an Assistant Professor at the University of Cukurova, Turkey, in 1994.

A key figure in Paxman's growth, Dr. Unver is credited with the patented design of the PSCS scalp cooling cap, introducing rapid cooling in sheet silicone thermoforming for the first time. His innovative contributions have been pivotal for Paxman's success. Dr. Unver has an impressive record of over 120 research articles, numerous keynote speeches, and active involvement in Innovate UK and EU-funded projects. His current research interests span mass customisation, medical product development, AR/VR applications for industrial design, anthropometric & ergonomics analysis, and 3D simulation.

Dr. Aishwarya Bandla (PhD)

Clinical Innovation Manager

Dr. Aishwarya Bandla, Clinical Innovation Manager at Paxman, has led the development of a wearable limb cryocompression devices to prevent chemotherapy-induced peripheral neuropathy. She holds a Ph.D. in Biomedical Engineering from the N.1 Institute for Health, National University of Singapore (NUS), specialising in wearable technology for cancer care. 

Dr. Bandla is an Insitute of Electrical and Electronics Engineers (IEEE) senior member, serving as Chairperson of the IEEE Engineering in Medicine and Biology Singapore chapter. She is also an Adjunct Senior Research Fellow and Head of Translational Core at NUS. A recipient of multiple awards, including Outstanding Mentor by the Singapore Medical Association Charity Fund, Dr. Bandla was named among Singapore's 100 Women in Tech in 2020 for her influential contributions to the tech industry.

Dipo Olaosun (BSc)

Product Design Researcher

Dipo Olaosun is a multidisciplinary Industrial Designer with a passion for technology, innovation, and creativity. With prior experience as a web developer, he strives to amalgamate technology within design to elevate user experiences which is highlighted within his work.

Currently a Product Designer at Paxman, he focuses on the well-being of patient battling chemotherapy-induced alopecia while developing new products. Concurrently, Dipo pursues a part-time Master's in Product Design Engineering, researching testing methods for medical wearables. He also shares his expertise as a part-time lecturer, guiding students in digital and visual communication at the University of Huddersfield.

Gayathri Kopattil (BSc)

KTP Associate

Gayathri, a medical product designer, who has completed a Knowledge Transfer Partnership (KTP) working on a project aiming to develop a preventive solution for Chemotherapy Induced Peripheral Neuropathy (CIPN), funded by Innovate UK. Leveraging academic knowledge and clinical insights, Gayathri is dedicated to designing innovative technology. Alongside her role in the project, Gayathri pursues an MA by Research in Art and Design, specialising in medical product development. With 4 years of industry experience, including work at Paxman's Research & Innovation centre, she brings valuable expertise to the project.

Ethan Morgan

Development Engineer

Ethan, a Development Engineer at Paxman, has over 5 years of industry experience, which began in production of the Paxman Scalp Cooling System (PSCS) and transitioned to the role of Service Engineer, refining his hands-on approach. Notably, he led the sustainable redesign of the PSCS cap and spearheaded the production of over 200 cryocompression systems for a major international clinical trial. Currently pursuing a level 3 NVQ Diploma in Mechanical Manufacturing Engineering, Ethan's diverse background spans mechanical engineering disciplines, including motor vehicle mechanics and camper van construction. His research interests encompass engineering, design for manufacture, additive manufacturing, and technical testing and validation. Passionate about hands-on work, Ethan brings invaluable expertise to Paxman's projects.

Jane Clayton (BSc Hons)

Design Research Consultant

Jane, a Design Research Consultant for Paxman's SMART project, specialises in medical cooling and patient-centred design. With a first-class Biology degree from The University of Leeds, Jane's journey with Paxman began in 2010 through an R&D internship, evolving into European research funding expertise. Joining Paxman's Research & Innovation Centre in 2019, Jane coordinated impactful studies and secured funding for projects such as eco-design and innovative manufacturing for enhanced patient access to scalp cooling (InnovateUK SMART, £500k, 2022-2024). She is also involved in developing medical cooling solutions to prevent chemotherapy-induced peripheral neuropathy (KTP, 2022-2024).

Riley Irving

Product Design Placement 

Riley Irving is a Product Design (BSc) student currently working as part of the research and development department at Paxman. His main areas of interest include, designing medical products that make a positive impact on people’s lives and investigating modern design technologies such as artificial intelligence and virtual reality to see how viable they are as industrial design techniques. He also enjoys using software such as Blender and Keyshot to create digitally rendered visuals and animations to represent products.
© Paxman Coolers 2022